I have learned the hard way that any over the counter pain reliever has side affects. Had been taking Advil every 4 hours for Migraine headaches, then started taking Excedrin Migraine. I am now suffering from damaged kidneys because of it. Every thing else has been ruled out. I have learned that tylenol can damage your liver, what the heck is left? I still have migraines and osteo arthritis, so not suppose to take anything for that? I cannot go all day for sometimes more than 5 days out of the month with migraine pain.